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Thyrox 25mcg Tablet Pot
Thyrox contains Levothyroxine Sodium, a synthetic version of the naturally occurring hormone T4, secreted by the thyroid gland. In the body, around 30% of T4 is converted to the more active form, Triiodothyronine (T3). Most T4 binds to Thyroxine-Binding Globulin (TBG), prolonging its half-life. Only a tiny fraction (~0.03%) remains unbound and active.
Elimination half-life: 6–7 days (shorter in hyperthyroidism, longer in hypothyroidism).
Metabolism: Mainly in the liver with enterohepatic recycling.
A single daily dose is typically sufficient to maintain stable T3 levels.
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✅ Description:
- Used as replacement therapy in all forms of hypothyroidism except transient cases during recovery from subacute thyroiditis.
- For TSH suppression in patients with goitre, thyroid nodules, or post-treatment of thyroid cancer.
- To counteract the goitrogenic effects of certain medications, such as lithium.
- As a diagnostic agent in thyroid suppression testing.
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✔️ Side Effects
Usually linked to overdosage, mimicking hyperthyroidism:
- General: Weight loss, fatigue, heat intolerance, sweating
- CNS: Headache, insomnia, nervousness, anxiety
- Muscle: Tremors, weakness
- Cardiac: Palpitations, tachycardia, arrhythmias, increased BP
- GI: Diarrhea, vomiting, abdominal pain
- Skin: Hair thinning, flushing
- Respiratory: Shortness of breath
✔️ Dosage & Administration
Adults:
- Initial dose: 25–50 mcg/day, gradually increasing every 6–8 weeks in 12.5–25 mcg steps until TSH normalizes.
- Severe hypothyroidism: Start with 12.5–25 mcg/day and increase every 2–4 weeks with TSH monitoring.
- Secondary or tertiary hypothyroidism: Adjust dose to normalize free T4.
- Older adults or cardiac patients: 1.7 mcg/kg/day.
Pediatric:
- Newborns: 10–15 mcg/kg/day; use a lower dose if there's a cardiac risk.
- Infants/Children: Start with 25 mcg/day for severe cases, increase every 2–4 weeks as needed.
By age group:
0–3 months: 10–15 mcg/kg/day
3–6 months: 8–10 mcg/kg/day
6–12 months: 6–8 mcg/kg/day
1–5 years: 5–6 mcg/kg/day
6–12 years: 4–5 mcg/kg/day
12 years (growth/pubertal incomplete): 2–3 mcg/kg/day
After puberty: 1.7 mcg/kg/day
Dose adjustments should be based on clinical status and lab results.
✔️ Drug Interactions
- May enhance effects and toxicity of tricyclic antidepressants, increasing risk of arrhythmias and CNS stimulation.
- Sertraline may increase levothyroxine requirements.
- Can alter insulin or antidiabetic medication needs—monitor glucose levels closely.
- Digitalis effectiveness may be reduced as thyroid function improves.
✔️ Contraindications
- Untreated thyrotoxicosis
- Acute myocardial infarction
- Uncorrected adrenal insufficiency
✔️ Use in Pregnancy & Lactation
- Pregnancy Category A: Safe when clinically indicated; dosage may need adjustment.
- Minimal transfer to breast milk, but adequate dosing is essential for lactation and infant development.
✔️ Precautions
- Adrenal insufficiency should be addressed before starting therapy to avoid adrenal crisis.
- Use caution in cardiac patients and the elderly; avoid rapid dose escalation.
- Monitor for dosage adjustments if body weight changes significantly.
- TSH and free T4 should be monitored to maintain target levels and prevent overdose.
✔️ Storage:
Store below 30°C, in a dry, light-protected area.
Keep out of reach of children.
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here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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